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« Pharmaceutical News by Press Release? (OR: Low Dose Naltrexone Study Doesn't Make the News) | Main | Burt Berkson, MD, PhD, Talks With Honest Medicine About His Work and Our Medical System: The Interview Transcribed »

February 27, 2009


Gregory D. Pawelski

Interesting evaluation of Alpha Lipoic Acid as an intravenous drug instead of an pill.

Subsequent studies failed to show a benefit of oral-dose vitamin C as a treatment for cancer. However, a newer study involved injectons of vitamin C to enable greater concentrations of it to get into the system.

High-dose injections of vitamin C reduced tumor weight and growth rate by about 50% in mouse models of brain, ovarian, and pancreatic cancers. The researchers traced vitamin C's anti-cancer effect to the formation of hydrogen peroxide in the extracellular fluid surrounding the tumors. Normal cells were unaffected.

Also, vitamin C may act as an antioxidant, protecting cells from the damaging effects of free radicals. Researchers tested the idea that vitamin C, when injected at high doses, may have prooxidant instead of antioxidant activity. Prooxidants would generate free radicals and the formation of hydrogen peroxide, which might kill tumor cells.

And of course, Lipoic acid is the most versatile and powerful of all antioxidants. It is the antioxidant's antioxidant. Unlike any other antioxidant, it is both fat and water soluble and able to work in both the watery and fatty portions of the cell, wherever it is most needed.

When other antioxidants are exhausted and depleted, lipoic acid restores it to its full antioxidant effects. It is the only antioxidant that can reinvent itself as an antioxidant after it has expended itself fighting off free radical assaults.

It seems like the same thought processes were involved when researchers found that talc has the ability to stunt cancer growth by cutting the flow of blood to metastatic lung tumors. The talc stimulates healthy cells to produce 10-fold higher levels of endostatin, a hormone released by healthy lung cells.

Researchers rethought the situation by understanding that by allowing talc in the chest cavity, thus constantly causing normal cells to produce endostatin, it inhibits the growth of tumors. Talc causes tumor growth to slow down and actually decreases the tumor bulk.

Previous studies had been disappointing with pharma endostatin because most clinicians had injected the hormone directly into patients, where the hormone broke down in the body before it had a chance to slow the spread of cancer.

"Whiz bang" science often gets a pass without much thought. The problem is that few scientific discoveries work the way we think and few physicians/scientists take the time to think through what it is they discovered. I am glad a few do!

The FDA has never approved a drug for cancer that was not patented or marketed or produced by a major pharmaceutical company. The trend is towards more expensive cancer therapies with some costing up to $100,000 per patient per year.

Millions of patients have suffered and died and will continue to suffer and die because profitability, not efficacy and safety, is ultimately determing what cancer therapies are available to patients.

MaryJo Butitta

I have RA and am on LDN, for a little over a month. So far I have not had relief. Perhaps I should see Dr Berkson or at least see if my doctor would administer ALA. Great interview! Thank you!


i have tried to listen to the interview -i only get an error message


have you ever treated Alopecia Universal with LDN and liopoic acid

Thank you!

Gerome Jackson.

Dr nathan Stein

to the patient with RA: please persevere at least 6 months. Dr Stein, Manchester

Dr nathan Stein

has anyone improved from peptic ulcer with LDN?
Nathan Stein

Steve Sollars

Have you had any success with patients with Vitaligo?


Have you had any success with fibromyalgia, psoriasis or hashimoto thyroditus?


I have RA. I have been trying 1.5mg ldn. I have not been able to get past the insomnia and intense shoulder/neck pain when I take it. Has anyone else had this experience?

Daniel Smith

I am interested to know of any results obtained from Low Dose Naltrexone treatment of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP).

Melinda storer

Very good Medicines as well as without any side effect which gives complete relif
of any sickness.awesome!!! site.

Melinda storer

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thanks Doctor for share this information about Audio Interview: Burt Berkson, MD, PhD, Talks With Honest Medicine About His Work With Alpha Lipoic Acid and Low Dose Naltrexone with us !! I really appreciate your help

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Your blog posting is very good and theme base for which it is liking to every people.Thanks for all information about Burt Berkson, MD, PhD, Talks With Honest Medicine About His Work With Alpha Lipoic Acid and Low Dose Naltrexone


I know ALA is used to treat diabetes type 2. What about cardiomyopathy?

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Burt Berkson is a good personality.He is a person who is known through out the world for his effective contribution.

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His contributions to the medicine world have been tremendous, great article.

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I know ALA is used to treat diabetes type 2. What about cardiomyopathy?

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Good Post.This is the story of an inexpensive, very effective treatment which initially received support from the National Institutes of Health, but was, in the end, abandoned, because no pharmaceutical company would take up the expensive task of officially studying the drug. Thanks

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Thx a lot for the audio interview. This is a great idea

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